Pierfrancesco Mai, 65, is a doctor who works as a night watchman. He is also a man full of aches and pains, gruff and not at all empathetic to patients. One night he has an accident with Mario, a 30-year-old rider who is a food delivery man. Mario escapes unharmed, but his bike is destroyed. Because of the impact, Pierfrancesco, on the other hand, sees his perennial sciatica flare up and can no longer ride. The two are in danger of losing their jobs, but the doctor comes up with an idea that saves them both: Mario, “guided” remotely by Pierfrancesco via an earpiece, will go make the visits for him, and in the doctor’s car they will also make home deliveries. After a series of daring (dis)adventures, the two will learn to support each other and the night will come to an end, changing their lives for the better.